Comparison of the Outcomes of the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants

Document Type : Original Article

Authors

1 Mother and Newborn Health Research Center, Comprehensive Research Institute for Maternal and Child Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Community and Preventive Medicine, Health Monitoring Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Respiratory distress syndrome (RDS) in premature infants results from surfactant deficiency. Given the high cost and limited availability of Curosurf, we compared its outcomes with the Iranian surfactant Beracsurf.
Methods: This descriptive cross-sectional study included premature infants (≤34 weeks) with RDS who met surfactant criteria. We assessed hospitalization duration, mechanical ventilation time, delivery mode, CPAP duration, Apgar score, gestational age, and clinical outcomes (discharge/mortality). Complications (pneumothorax, pulmonary/intraventricular hemorrhage, BPD, ROP, NEC), surfactant redosing frequency, and time to FiO₂<40% were compared between groups.
Results: A total of 80 infants were divided into two equal groups (40 each). Baseline demographics were similar (P>0.05). Beracsurf recipients required significantly longer mechanical ventilation (3.25 vs. 2.22 days, P=0.01) and CPAP (3.05 vs. 2.41 days, P=0.04) than Curosurf recipients. No significant differences were observed in other complications, hospitalization duration, or mortality.
Conclusion: Curosurf provided significantly shorter durations of respiratory support compared to Beracsurf. Other outcomes and complication rates were comparable. Further large-scale studies are warranted to guide clinical and economic decisions.

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History

  • Receive Date: 21 July 2026
  • Accept Date: 21 July 2026

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