Applications of Artificial Intelligence Chatbots in Congenital Diplopodia: A Real-World Perspective on a Rare Case of Duplicated Lower Limb

Document Type : Original Article

Authors

1 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran

4 Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran

5 Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

6 Department of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, USA

7 Department of Radiology, Shahid Rahnamoun Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

8 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: This study examines the effectiveness of AI chatbot technology in assisting patients with congenital diplopia, focusing on a case study of a 16-month-old boy with duplicated lower limbs.
Methods: We assessed the performance of two AI chatbots—Sider Fusion AI and Perplexity AI—by analyzing their discharge summaries against a previously published clinical scenario. An orthopedic specialist, geneticist, and neonatologist evaluated the summaries for competence, accuracy, relevance, informativeness, support capabilities, and overall communication effectiveness.
Results: Both chatbots produced organized summaries that accurately reflected the diagnosis and surgical procedure outlined by Dr. Kitta. However, Sider Fusion AI surpassed Perplexity AI in organization and detail, offering structured summaries with clear headings and bullet points. It included comprehensive information on patient care, dietary advice, genetic testing, family support, follow-up instructions, pain management, and Ankle-Foot Orthosis (AFO) guidelines. In contrast, Perplexity AI's summary, while accurate, was less specific and clear, conflating care instructions with vague mobility information.
Conclusion: The findings suggest that while AI chatbots can aid in clinical documentation, their effectiveness varies significantly, with Sider Fusion AI providing a more structured and practical resource for families and practitioners dealing with congenital orthopedic disorders.

Keywords


Corresponding Author: Seyedeh Elham Shams

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  1. Kitta MI, Azis HS, Santoso NY, Iswahyudi, Fahlevi RR, Arden F. Congenital diplopodia-A rare case of duplicated lower limb: A case report. International journal of surgery case reports. Int J Surg Case Rep 2021; 87: 106390.
  2. Tickle C, Towers M. Sonic hedgehog signaling in limb development. Front Cell Dev Biol 2017; 5: 14.
  3. Umair M, Ahmad F, Bilal M, Ahmad W, Alfadhel M. Clinical genetics of polydactyly: an updated review. Front Genet 2018; 9: 447.
  4. Hayashi S, Akiyama R, Wong J, Tahara N, Kawakami H, Kawakami Y. Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development. PLoS Genet 2016; 12(6): e1006138.
  5. Xie P, Yuan F-Q, Zhou H-H, Li X, Liu Z-Q. The molecular genetics related to polydactyly: an updated review. Pharmacogenomics Res Pers 2021; 2–12.
  6. Kyriazis Z, Kollia P, Grivea I, Stefanou N, Sotiriou S, Dailiana ZH. Polydactyly: Clinical and molecular manifestations. World J Orthop 2023; 14(1): 13–22.
  7. Levinsohn EM, Hootnick DR, Packard DS. Consistent arterial abnormalities associated with a variety of congenital malformations of the human lower limb. Investigative Radiology. Invest Radiol 1991; 26(4): 364–73.
  8. Duan R, Hijazi H, Gulec EY, Eker HK, Costa SR, Sahin Y, et al. Developmental genomics of limb malformations: Allelic series in association with gene dosage effects contribute to the clinical variability. HGG advances. HGG Adv 2022; 3(4): 100132.
  9. Woodacre T, Dunkerley S, Cox PJ. A rare case of mobile diplopodia mistaken for polydactyly. Arch Clin Cases 2023; 10(1): 15–7.
  10. Brower JS, Wootton-Gorges SL, Costouros JG, Boakes J, Greenspan A. Congenital diplopodia. Pediatr Radiol 2003; 33(11): 797-9.
  11. Chawathe VS, Gaur AK, Athani BD, Gupta S. Proximal femoral focal deficiency associated with fibular duplication and diplopodia and complete agenesis of the tibia: a case report. J Pediatr Orthop B; 2017; 26: 358–61.
  12. Aggarwal A, Tam CC, Wu D, Li X, Qiao S. Artificial intelligence-based chatbots for promoting health behavioral changes: systematic review. J Med Internet Res 2023; 25: e40789.
  13. Oh YJ, Zhang J, Fang ML, Fukuoka Y. A systematic review of artificial intelligence chatbots for promoting physical activity, healthy diet, and weight loss. Int J Behav Nutr Phys Act 2021; 18: 160.
  14. Oleck NC, Naga HI, Nichols DS, Morris MX, Dhingra B, Patel A. Navigating the Ethical Landmines of ChatGPT: Implications of Intelligent Chatbots in Plastic Surgery Clinical Practice. Plast Reconstr Surg Glob Open 2023; 11(9): e5290.
  15. Hwang GJ, Chang CY. A review of opportunities and challenges of chatbots in education. Interactive Learning Environments 2023; 31(7): 4099–112.
  16. Altamimi I, Altamimi A, Alhumimidi AS, Altamimi A, Temsah M-H. Artificial Intelligence (AI) Chatbots in Medicine: A Supplement, Not a Substitute. Cureus 2023; 15(6): e40922.
  17. Abreu AA, Murimwa GZ, Farah E, Stewart JW, Zhang L, Rodriguez J, et al. Enhancing readability of online patient-facing content: the role of ai chatbots in improving cancer information accessibility. J Natl Compr Canc Netw 2024; 22(2 D): e237334.
  18. Liao CY, Chu CN, Lien MY, Wu YC, Wang TH. AI-Enhanced Healthcare: Integrating ChatGPT-4 in ePROs for Improved Oncology Care and Decision Making:A pilot Evaluation. Current Oncology. 2025; 32(1):7.
  19. Sharma D, Kaushal S, Kumar H, Gainder S. Chatbots in Healthcare: Challenges, Technologies and Applications. Proceedings of the AIST 2022 - 4th International Conference on Artificial Intelligence and Speech Technology. Institute of Electrical and Electronics Engineers Inc. Delhi, India: 09-10 December 2022.
  20. Ali O, Abdelbaki W, Shrestha A, Elbasi E, Alryalat MAA, Dwivedi YK. A systematic literature review of artificial intelligence in the healthcare sector: Benefits, challenges, methodologies, and functionalities. Journal of Innovation & Knowledge 2023; 8(1): 100333.