Investigation of the Frequency of IL27 Gene -964 A>G Polymorphism (rs153109) in Infants with a History of Heart Wall Defects in Yazd

Document Type : Original Article

Authors

1 Dr. Mazaheri’s Medical Genetics Lab, Yazd, Iran

2 Department of Biological Sciences, Faculty of Engineering and Science, Science and Arts University, Yazd, Iran

3 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Congenital Heart Disease (CHD) is one of the leading causes of infant mortality with some problems in the heart's structure at birth. One of the most common congenital heart diseases is the septal defect, in which there is a hole in the wall (septum). Although the etiology of CHD is mainly unknown, numerous studies have suggested both genetic and environmental factors contribute to the development of this disease. This study aims to investigate the frequency of -964 A>G polymorphism (rs153109) in the IL27 gene in infants with CHD in Yazd province, Iran.
Methods: The study included 30 infants with CHD. We genotyped the IL27 polymorphism by using the PCR- Sequencing technique.
Results: Data revealed that the frequencies of AA, AG, and GG among the population of Yazd province were 40%, 40%, and 20%, respectively. The frequency of A and G alleles were 60% and 40%, respectively.
Conclusion: The higher frequency of the A allele in patients with CHD compared to the G allele suggests that the A allele may increase atrial septal defect and ventricular septal defect susceptibility in Yazd province. It is recommended that the presence of the A allele and AG genotype be used as a predictor for the development of septal defects.

Keywords

Corresponding Author: Mahta Mazaheri
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References

  1. Zaidi S, Brueckner M. Genetics and genomics of congenital heart disease. Circ Res 2017; 120(6): 923-40.
  2. Zhao L, Chen L, Yang T, Wang T, Zhang S, Chen L, et al. Birth prevalence of congenital heart disease in China, 1980–2019: a systematic review and meta-analysis of 617 studies. Eur J Epidemiol 2020; 35(7): 631-42.
  3. Blue GM, Kirk EP, Sholler GF, Harvey RP, Winlaw DS. Congenital heart disease: current knowledge about causes and inheritance. Med J Aust 2012; 197(3): 155-9.
  4. Fahed AC, Gelb BD, Seidman J, Seidman CE. Genetics of congenital heart disease: the glass half empty. Circ Res 2013; 112(4): 707-20.
  5. Boyd R, McMullen H, Beqaj H, Kalfa D. Environmental exposures and congenital heart disease. Pediatrics 2022; 149(1): e2021052151.
  6. Kalisch-Smith JI, Ved N, Sparrow DB. Environmental risk factors for congenital heart disease. Cold Spring Harb Perspect Biol 2020; 12(3): a037234.
  7. Shabana NA, Shahid SU, Irfan U. Genetic contribution to congenital heart disease (CHD). Pediatr Cardiol 2020; 41(1): 12-23.
  8. Adamczak R, Ukleja-Sokołowska N, Lis K, Dubiel M. Function of follicular cytokines: roles played during maturation, development and implantation of embryo. Medicina (Kaunas) 2021; 57(11): 1251.
  9. Zhang D, Ma M, Yang Y, Wan L, Yang Z, Lv J, et al. Association between polymorphisms in IL27 and risk for CHD in a Chinese population. Cardiol Young 2016; 26(2): 237-43.
  10. Wang Q, Liu J. Regulation and immune function of IL-27. Regulation and Immune Function of IL-27. Adv Exp Med Biol 2016: 191-211.
  11. Jafarizade M, Kahe F, Sharfaei S, Momenzadeh K, Pitliya A, Zahedi Tajrishi F, et al. The role of interleukin-27 in atherosclerosis: A contemporary review. Cardiology 2021; 146(4): 517-30.
  12. Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, et al. Exome array analysis identifies a common variant in IL27 associated with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016; 194(1): 48-57.
  13. Huang N, Liu L, Wang X-Z, Liu D, Yin S-Y, Yang X-D. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. DNA Cell Biol 2008; 27(9): 527-31.
  14. Masjedy A, Salesi M, Ahmadi A, Salimian J, Jamalkandi SA. Association between single-nucleotide polymorphism of cytokines genes and chronic obstructive pulmonary disease: A systematic review and meta-analysis. Cytokine 2023; 171: 156352.
  15. Chen Y, Zhang R, Zeng L, Wei H, Chen Y, Zeng J. IL-27 genetic variation and susceptibility of dilated cardiomyopathy in Chinese Han population. Per Med 2017; 14(5): 401-8.
  16. Koohyanizadeh F, Falahi S, Mortazavi SHR, Salari F, Rezaiemanesh A, Karaji AG. Correlation between IL-27p28 Genetic Polymorphisms and Risk of Allergic Rhinitis. Gene Expression 2023; 22(4): 281-7.
  17. Shen Y, Yuan X-D, Hu D, Ke X, Wang X-Q, Hu G-H, et al. Association between interleukin-27 gene polymorphisms and susceptibility to allergic rhinitis. Hum Immunol 2014; 75(9): 991-5.
  18. Wei P, Kou W, Sun R, Hu G-h, Hu D, Feng J, et al. Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population. Eur Arch Otorhinolaryngol 2015; 272(4): 889-93.
  19. Yu JI, Han WC, Lee JH, Kim HS, Yun KJ, Lee JH, et al. Human IL-27p28 gene polymorphisms are associated with the serum total IgE levels of allergic rhinitis patients. Journal of Life Science 2009; 19(3): 299-304.
  20. Fan Q, Nie S, Li S, Liao Y, Zhang H, Zha L, et al. Analysis of the genetic association between IL27 variants and coronary artery disease in a Chinese Han population. S Sci Rep 2016; 6(1): 25782.
  21. Posadas-Sánchez R, Pérez-Hernández N, Rodríguez-Pérez J, Ángeles-Martínez J, Posadas-Romero C, Cardoso-Saldaña G, et al. PS230 Interleukin-27 Polymorphisms are Associated With Premature Coronary Artery Disease and Insulin Resistance. The Genetics of Atherosclerotic Disease (GEA) Mexican Study. Global Heart 2016; 11(2): e51.
  22. Zimmerman MS, Smith AGC, Sable CA, Echko MM, Wilner LB, Olsen HE, et al. Global, regional, and national burden of congenital heart disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Child Adolesc Health 2020; 4(3): 185-200.
  23. Damayantie V, Rahayuningsih SE, Afriandi I. Congenital heart disease characteristics in low birth weight infants at Dr. Hasan Sadikin General Hospital in 2010-2014. Althea Medical Journal 2019; 6(3): 115-22.
  24. Suluba E, Shuwei L, Xia Q, Mwanga A. Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways. Egypt J Med Hum Genet 2020; 21(1): 1-12.
  25. Shimizu M, Shimamura M, Owaki T, Asakawa M, Fujita K, Kudo M, et al. Antiangiogenic and antitumor activities of IL-27. J Immunol 2006; 176(12): 7317-24.
  26. Vignali DAA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol 2012; 13(8):722-8.
  27. Asadi S, Abkar M, Zamanzadeh Z, Taghipour Kamalabad S, Sedghi M, Yousefnia S. Association of SOD2 rs2758339, rs5746136 and rs2842980 polymorphisms with increased risk of breast cancer: a haplotype-based case-control study. Genes Genomics 2023: 45(9): 1165-78.
  28. Yousefnia S. Association between genetic polymorphism of catalase (CAT) C-262T, Cu/Zn superoxide dismutase (SOD1) A251G and risk of age-related macular degeneration. Molecular and Biochemical Diagnosis Journal 2014; 1(2): 77-88.

 

 

 

World Journal of Peri and Neonatology
Volume 6, Issue 2
June 2024
Pages 67-74

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History

  • Receive Date: 02 June 2024
  • Accept Date: 02 June 2024

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