A Case Report of Down Syndrome and β-Thalassemia Major Coincidence

Document Type : Case Report

Authors

1 Children Growth Disorder Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Pediatrics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

Abstract

Background: Down syndrome and β-thalassemia are commonly prevalent genetic diseases worldwide. Predominantly, an extra copy of chromosome 21 or trisomy 21 predominantly causes Down syndrome (the most common genetic etiology of moderate intellectual disability). Down syndrome is associated with congenital anomalies and characteristic features. β-thalassemia major or transfusion- dependent Thalassemia refers to a severe expression of the disorder that requires early transfusion therapy.
Case Report: Here, we reported a male Down syndrome patient with a 47, xy, +21 karyotype who was diagnosed with β-thalassemia major at 6 months and treated with repeated transfusions every 20 days due to anemia.
Conclusion: The association between Down syndrome and major β-thalassemia is rare. The severity of the presentation of the child may be explained by the coincidence of these diseases.

Keywords

Corresponding Author: Shima Mirhosseini

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World Journal of Peri and Neonatology
Volume 6, Issue 1
December 2023
Pages 61-63

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History

  • Receive Date: 06 December 2023
  • Accept Date: 06 December 2023
  • First Publish Date: 06 December 2023

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