The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice

Document Type : Scientific Review

Authors

1 Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

5 Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Neonatal jaundice is a common clinical problem caused by the deposition of bilirubin in the tissue. Natural products have long been used to treat jaundice, and Iranian medicine can be a good source of natural treatments for this purpose. In this study, we investigate the mechanism of the effect of Cotoneaster, an Iranian herbal medicine, in the treatment of jaundice in neonates.
Methods: We investigated every article that evaluated Purgative manna, Cotoneaster manna, or Cotoneaster in the treatment of neonatal jaundice. We searched the databases of PubMed, Scopus, Web of Sciences, SciELO, CNKI, and Google Scholar for English articles, and a search was also done in Persian in Magiran and Scientific Information Database (SID) published until August 2023.
Results: The exact mechanism of Cotoneaster in reducing jaundice is not known, but the following mechanisms have been suggested .The most common mechanisms include increased urination, increased bile excretion from the liver, and increased defecation, as well as neutralizing the effects of oxidative agents and free radicals.
Conclusion: Considering that most studies have stated that Cotoneaster combined with phototherapy is effective in treating jaundice and herbal medicines alone cannot treat jaundice. Therefore, identifying the mechanism of Cotoneaster in reducing jaundice can lead to the creation of methods to strengthen its effect. More detailed biochemical and pharmacological studies are needed to understand the mechanism of action of Cotoneaster in reducing neonatal jaundice.

Keywords

Corresponding Author: Sedigheh Ekraminasab
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References

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World Journal of Peri and Neonatology
Volume 6, Issue 1
December 2023
Pages 49-55

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History

  • Receive Date: 21 October 2023
  • Accept Date: 21 October 2023
  • First Publish Date: 01 December 2023

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