Incidence and Types of Congenital Anomalies in Newborns of Yazd Hospitals during Six Years (2016- 2021) Based on National Mother and Newborn Health Registration System

Document Type : Original Article

Authors

1 Department of Medical Ethics and Pediatrics, Faculty of Medicine, Shahed University, Tehran, Iran

2 Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Genetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

5 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6 Department of Midwifery, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Congenital anomalies are responsible for a remarkable proportion of disability and mortality in newborns. Therefore, the aim of this study is to investigate the incidence and types of congenital anomalies in newborns born in Yazd hospitals during the years 2016 to 2021.
Methods: In this cross-sectional descriptive study, the data of all live births from 2016 to 2021 in hospitals of Yazd were extracted from the database of the National Mother and Newborn Health Registration System of Shahid Sadoughi University of Medical Sciences.
Results: From a total of 151,566 live births during six years, congenital anomalies were seen in 1338 (0.88%) newborns. The most common congenital anomalies involved the cardiovascular system (0.31%), followed by musculoskeletal anomalies (0.16%), gastrointestinal tract (0.14%), and genital system (0.1%), respectively. The incidence increased from 0.63% in 2016 to 1.05% in 2021, with the highest incidence observed in 2020 (1.31%).
Conclusion: The incidence of congenital anomalies in Yazd is lower than in most studies in Iran. However, shows an increasing trend over the years which can be due to the improvement of diagnostic methods especially in the case of congenital heart anomalies. However, more extensive studies on maternal risk factors and neonatal outcomes are needed.

Keywords

Corresponding Authors: Shiva Rafati & Mahta Mazaheri


You can search for Shiva Rafati in PubMed     Google Scholar Profile   View Orcid in Profile

You can search for Mahta Mazaheri in PubMed     Google Scholar Profile    View Orcid in Profile

References

1. Geneti SA, Dimsu GG, Sori DA, Amente LD, Kurmane ZM. Prevalence and patterns of birth defects among newborns in southwestern Ethiopia : a retrospective study. Pan Afr Med J 2021; 21(40): 248.
2. Alijahan R, Mirzarrahimi M, Ahmadi Hadi P, Hazrati S. Prevalence of congenital abnormalities and its related risk factors in Ardabil, Iran, 2011 [in Persian]. Iran J Obstet Gynecol Infertil 2013; 16(54): 16-25.
3. Vatankhah S, Jalilvand M, Sarkhosh S, Azarmi M, Mohseni M. Prevalence of congenital anomalies in iran: A review article. Iran J Public Health 2017; 46(6): 733-43.
4. Shi Y, Zhang B, Kong F, Li X. Prenatal limb defects: Epidemiologic characteristics and an epidemiologic analysis of risk factors. Medicine (Baltimore) 2018; 97(29): e11471.
5. Wang H, Barisic I, Loane M, Addor MC, Bailey LM, Gatt M, et al. Congenital clubfoot in Europe: A population-based study. Am J Med Genet Part A 2019; 179(4): 595-601.
6. Kozovyi R, Kovalchuk L, Kitsera N. The frequency and spectrum of birth defects among 486 longlivers from Ivano-Frankivsk region (West Ukraine). Trends Med 2020; 20(5): 1-4.
7. Rostamizadeh L, Bahavarnia SR, Gholami R. Alteration in incidence and pattern of congenital anomalies among newborns during one decade in Azarshahr, Northwest of Iran. Int J Epidemiol Res 2017; 4(1): 37-43.
8. DeSilva M, Munoz FM, Mcmillan M, Kawai AT, Marshall H, Macartney KK, et al. Congenital anomalies: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 2016; 34(49): 6015-26.
9. Shawky RM, Sadik DI. Congenital malformations prevalent among Egyptian children and associated risk factors. Egypt J Med Hum Genet 2011; 12(1): 69-78.
10. Taye M, Afework M, Fantaye W, Diro E, Worku A. Congenital anomalies prevalence in Addis Ababa and the Amhara region, Ethiopia: A descriptive cross-sectional study. BMC Pediatr 2019; 19(1): 234.
11. Sitkin NA, Ozgediz D, Donkor P, Farmer DL. Congenital anomalies in low- and middle-income countries: The unborn child of global surgery. World J Surg 2015; 39(1): 36-40.
12. Shalaby AM, EL-Gazzar AF. The frequency, types and risk factors of congenital anomalies in a tertiary neonatal intensive care unit (A hospital based study) Amira. Ann Neonatol J 2020; 3(1): 24-45.
13. Zahed Pasha Y, Vahedi A, Zamani M, Alizadeh-Navaei R, Zahed Pasha E. Prevalence of birth defects in Iran: A systematic review and meta-analysis. Arch Iran Med 2017; 20(6): 376-85.
14. Mohseni F, Mousavi MH, Ahmadi A, Hosseinnataj A, Marvi N, Ghazanfarpour M, et al. Examining prevalence of fetal defects and related factors in neonates born and hospitalized in Kerman Reference Hospital : A 66-month study. Int J Pediatr 2021; 9(6): 13653-62.
15. Irani M, Khadivzadeh T, Asghari Nikah SM, Ebrahimipour H, Tara F. The prevalence of congenital anomalies in Iran: A Systematic Review and Meta-analysis [in Persian]. Iran J Obstet Gynecol Infertil 2017; 21(Suppl): 29-41.
16. Abdou MSM, Sherif AAR, Wahdan IMH, Din Ashour KSE. Pattern and risk factors of congenital anomalies in a pediatric university hospital, Alexandria, Egypt. J Egypt Public Health Assoc 2019; 94(1): 3.
17. Forci K, Alami MH, Bouaiti E, Slaoui M, Mdaghri Alaoui A, Thimou Izgua A. Prevalence of congenital malformations at the “les Orangers” maternity and reproductive health Hospital of Rabat: Descriptive study of 470 anomalies. BMC Pediatr 2020; 20(1): 272.
18. Motamadinasab M, Dastgheib SA, Golshan-Tafti M, Bahrami R, Javaheri A, Tabatabaie RS, et al. Association of TCF7L2 polymorphisms with susceptibility to gestational diabetes mellitus: A systematic review and meta-analysis. World J Peri & Neonatol 2021; 4(2): 88-103.
19. Askari M, Dadbinpour A, Ekraminasab S, Shukohifar M. Incidence and risk factors related to gestational diabetes mellitus among women in Yazd: A prospective cohort study. World J Peri & Neonatol 2022; 5(2): 65-73.
20. Farzan F, Dadbinpour A, Ekraminasab S, Fallahzadeh H, Mazaheri M. Positive predictive value of screening tests in the first and second trimester of pregnancy in the diagnosis of trisomy 21, 18, and 13 using amniocentesis. World J Peri Neonatol 2022; 5(2): 74-82.
21. Daliri S, Sayehmiri K, Asadollahi K, Rezaei N, Saroukhani D, Karimi A. Prevalence of congenital anomalies in iran: A systematic review and meta-analysis. Iran J Neonatol 2018; 9(2): 22-32.
22. Davari HA, Javanmardi Z, Hooshangi Z, Moazem E. Major congenital anomalies and associated risk factors in isfahan province, iran, 2014-2015 [in Persian]. J Isfahan Med Sch 2019; 37(513): 9-15.
23. Lookzadeh MH, Alipour MR, Vakili-Zarch A, Ekraminasab S. Prevalence of congenital heart diseases in neonates of diabetic mothers: A Cross Sectional Study in Yazd. World J Peri & Neonatol 2022; 5(1): 24-9.
24. Lookzadeh MH, Alipour MR, Vakili Zarch A, Ekraminasab S. Prevalence of hypertrophic cardiomyopathy in neonates of diabetic mothers: A six-month follow-up study. World J Peri & Neonatol 2022; 5(2): 58-64.
25. Saragard Kermani E, Nazari Z, Mehdizadeh M, Shahbazi M, Golalipour MJ. Gestational diabetes influences the expression of hypertrophic genes in left ventricle of rat’s offspring. Iran J Basic Med Sci 2018; 21(5): 525-8.
26. Kamal NM, Othman N. Incidence and types of congenital anomalies in newborns in sulaimaniyah city in Iraq. Acta Med Iran 2018; 56(12): 769-76.
World Journal of Peri and Neonatology
Volume 6, Issue 1
December 2023
Pages 17-25

Files

History

  • Receive Date: 04 October 2023
  • Accept Date: 04 October 2023

Share

How to cite

Statistics