Positive Predictive Value of Screening Tests in the First and Second Trimester of Pregnancy in the Diagnosis of Trisomy 21, 18, and 13 Using Amniocentesis

Document Type : Original Article

Authors

1 The Ali-ibne-Abitaleb School of Medicine, Islamic. Azad University of Yazd, Yazd, Iran

2 Genetic and Environmental Adventures Research Center, School of Abarkouh paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

5 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6 Research Center of Prevention and Epidemiology of Non-Communicable Disease, Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

7 Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: The aim of this study is to analyze the positive predictive value (PPV) of trisomies 21, 18 and 13 at first and second trimester using amniocentesis for clinical practice.
Methods: : This is a descriptive cross-sectional study in which data were extracted from a cohort project of mother and infant conducted between March 2016 and February 2021 among 3110 pregnant women in Yazd city.
Results: Out of 3110 pregnant women, 84 mothers were at high risk in the screening tests of the first and second trimesters of pregnancy and therefore were candidates for amniocentesis. None of them were detected by the positive amniocentesis method. The mean age of mothers was 33.2 years. The causes of amniocentesis included old age (45.9%), positive results of Down syndrome screening (23%), high NT ultrasound (4.9%), and pathological results of anomaly scan sonography (3.8%).
Conclusion: In this study, the PPV was zero and the number of false positives in screening tests was 84 (100%). This may be because our population was normal and had no history of genetic abnormalities or other special conditions.

Keywords

References

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World Journal of Peri and Neonatology
Volume 5, Issue 2
December 2022
Pages 74-82

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History

  • Receive Date: 28 December 2022
  • Accept Date: 28 December 2022

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