Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis

Document Type : Systematic Review

Authors

1 Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Cardiology, Firoozgar Hospital Research Center, Iran University of Medical Sciences, Tehran, Iran

4 Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

5 Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

6 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

7 Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Studies investigating the association between ITPKC rs28493229 polymorphisms and Kawasaki disease (KD) risk found inconsistent data. Thus, we performed this meta-analysis to combine and analyze the available studies to get a precise estimation of the association.
Methods: Relevant studies identified in the PubMed, Web of Science, Scopus, and CNKI databases were used to perform a meta-analysis. Pooled odds ratios (OR) with a 95% confidence interval (95% CI) were calculated under fixed- and random-effects models to appraise the association.
Results: A total of eight case-control studies with 2,721 KD cases and 5,307 controls were selected. The results showed a statistically significant association between ITPKC rs28493229 polymorphism and an increased risk of KD under all five genetic models, i.e., allele (C vs. G: OR = 1.434, 95% CI 1.209-1.700, P ≤ 0.001), homozygote (CC vs. GG: OR = 2.085, 95% CI 1.423-3.055, P ≤ 0.001), heterozygote (CG vs. GG: OR = 1.530, 95% CI 1.359-1.722, P ≤ 0.001), dominant (CC+CG vs. GG: OR = 1.490, 95% CI 1.229-1.806, P ≤ 0.001), and recessive (CC vs. CG + GG: OR = 1.799, 95% CI 1.231-2.629, P = 0.002) in the overall population. When stratified by country, there was a significant association among Taiwanese.
Conclusion: Our meta-analysis results supported that the ITPKC rs28493229 polymorphism is strongly associated with susceptibility to KD.

Keywords

References

  1. Gorczyca D, Postępski J, Olesińska E, Lubieniecka M, Lachór-Motyka I, Opoka-Winiarska V, et al. The clinical profile of Kawasaki disease of children from three Polish centers: A retrospective study. Rheumatol Int 2014; 34(6): 875-80.
  2. Ferdosian F, Dastgheib SA, Hosseini-Jangjou SH, Nafei Z, Lookzadeh MH, Noorishadkam M, et al. Association of TNF-α rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 polymorphisms with susceptibility to Kawasaki disease: A comprehensive meta-analysis. Fetal Pediatr Pathol 2021; 40(4): 320-36.
  3. Ferdosian F, Dastgheib SA, Morovati-Sharifabad M, Lookzadeh MH, Noorishadkam M, Mirjalili SR, et al. Cumulative evidence for association between IL-10 polymorphisms and Kawasaki disease susceptibility: A systematic review and meta-analysis. Fetal Pediatr Pathol 2021; 40(2): 153-65.
  4. Lau AC. Coronary artery outcome in Kawasaki disease : the role of matrix metalloproteinase-9 and therapeutic modulation of its activity. [Thesis]. Toronto, CA: University of Toronto; 2008.
  5. Nakamura Y, Yashiro M, Uehara R, Sadakane A, Tsuboi S, Aoyama Y, et al. Epidemiologic features of Kawasaki disease in Japan: results of the 2009-2010 nationwide survey. J Epidemiol 2012; 22(3): 216-21.
  6. Salo E, Griffiths EP, Farstad T, Schiller B, Nakamura Y, Yashiro M, et al. Incidence of Kawasaki disease in northern European countries. Pediatr Int 2012; 54(6): 770-2.
  7. Harnden A, Mayon-White R, Perera R, Yeates D, Goldacre M, Burgner D. Kawasaki disease in England: ethnicity, deprivation, and respiratory pathogens. Pediatr Infect Dis J 2009; 28(1): 21-4.
  8. Pilania RK, Bhattarai D, Singh S. Controversies in diagnosis and management of Kawasaki disease. World J Clin Pediatr 2018; 7(1): 27-35.
  9. Marchesi A, De Jacobis IT, Rigante D, Rimini A, Malorni W, Corsello G, et al. Kawasaki disease: Guidelines of the Italian Society of Pediatrics, part i - Definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase. Ital J Pediatr 2018; 44(1): 102.
  10. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004; 110(17): 2747-71.
  11. Tremoulet AH. Adjunctive therapies in Kawasaki disease. Int J Rheum Dis 2018; 21(1): 76-9.
  12. Hsieh KS, Weng KP, Lin CC, Huang TC, Lee CL, Huang SM. Treatment of acute Kawasaki disease: Aspirin’s role in the febrile stage revisited. Pediatrics 2004; 114(6): e689-93.
  13. Behjati-Ardakani M, Ferdosian F. Multiple giant succular and fusiform right and left coronary artery aneurysms after early and adequate treatment of atypical kawasaki disease with unusual presentation. Acta medica Iranica 2014; 52(6): 490-2.
  14. Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW, Yashiro M, et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 2008; 40(1): 35-42.
  15. Lloyd AJ, Walker C, Wilkinso M. Kawasaki disease: is it caused by an infectious agent? Br J Biomed Sci 2001; 58(2): 122-8.
  16. Uehara R, Yashiro M, Nakamura Y, Yanagawa H. Parents with a history of Kawasaki disease whose child also had the same disease. Pediatr Int 2011; 53(4): 511-4.
  17. Chi H, Huang FY, Chen MR, Chiu NC, Lee HC, Lin SP, et al. ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children. Hum Mol Genet 2010; 19(6): 1147-51.
  18. Lin MT, Wang JK, Yeh JI, Sun LC, Chen PL, Wu JF, et al. Clinical implication of the C allele of the ITPKC gene SNP rs28493229 in kawasaki disease: Association with disease susceptibility and BCG scar reactivation. Pediatr Infect Dis J 2011; 30(2): 148-52.
  19. Wang W, Lou J, Zhong R, Qi Y, Shen N, Lu X, et al. The roles of Ca2+/NFAT signaling genes in Kawasaki disease: single- and multiple-risk genetic variants. Sci Rep 2014; 4: 5208.
  20. Kuo HC, Chang WC. Genetic polymorphisms in Kawasaki disease. Acta Pharmacol Sin 2011; 32(10): 1193-8.
  21. Kim KY, Bae YS, Ji W, Shin D, Kim HS, Kim DS. ITPKC and SLC11A1 gene polymorphisms and gene-gene interactions in Korean patients with Kawasaki disease. Yonsei Med J 2018; 59(1): 119-27.
  22. Niktabar SM, Aarafi H, Dastgheib SA, Noorishadkam M, Mirjalili SR, Lookzadeh MH, et al. Association of MTHFR 1298A > C polymorphism with susceptibility to non-syndromic cleft lip with or without palate: A case-control study and meta-analysis. Fetal Pediatr Pathol 2021; 40(1): 1-17.
  23. Bahrami R, Dastgheib SA, Niktabar SM, Amooee A, Lookzadeh MH, Mirjalili SR, et al. Association of BMP4 rs17563 polymorphism with nonsyndromic cleft lip with or without cleft palate risk: Literature review and comprehensive meta-analysis. Fetal Pediatr Pathol 2020; 40(4): 305-19.
  24. Onouchi Y, Suzuki Y, Suzuki H, Terai M, Yasukawa K, Hamada H, et al. ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease. Pharmacogenomics J 2013; 13(1): 52-9.
  25. Kuo HC, Yang KD, Juo SHH, Liang C Di, Chen WC, Wang YS, et al. Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population. PLoS One 2011; 6(4): e17370.
  26. Peng Q, Chen C, Zhang Y, He H, Wu Q, Liao J, et al. Single-nucleotide polymorphism rs2290692 in the 30UTR of itpkc associated with susceptibility to kawasaki disease in a han chinese population. Pediatr Cardiol 2012; 33(7): 1046-53.
  27. Natividad MF, Torres-Villanueva CAT, Saloma CP. Superantigen involvement and susceptibility factors in Kawasaki disease: profiles of TCR Vβ2+ T cells and HLA-DRB1, TNF-α and ITPKC genes among Filipino patients. Int J Mol Epidemiol Genet 2013; 4(1): 70-6.
  28. Lou J, Xu S, Zou L, Zhong R, Zhang T, Sun Y, et al. A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis. Mol Biol Rep 2012; 39(12): 11137-44.
  29. Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, et al. Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet 2011; 43(12): 1241-6.
  30. Salimi E, Karimi-Zarchi M, Dastgheib SA, Abbasi H, Tabatabaiee RS, Hadadan A, et al. Association of promoter region polymorphisms of IL-6 and IL-18 genes with risk of recurrent pregnancy loss: A systematic review and meta-analysis. Fetal Pediatr Pathol 2019; 39(4): 346-59.
  31. Veisian M, Tabatabaei RS, Javaheri A, Abbasi H, Salimi E, Hadadan A, et al. Association of interleukin-10 -1082G > A polymorphism with susceptibility to preeclampsia: A systematic review and meta-analysis based on 21 studies. Fetal Pediatr Pathol 2020; 39(6): 518-32.
  32. Veisian M, Javaheri A, Amjadi N, Tabatabaei RS, Zanbagh L, Hadadan A, et al. Association of IL-6 -176G > C polymorphism with susceptibility to preeclampsia: A systematic review and meta-analysis. Fetal Pediatr Pathol 2020; 39(6): 491-502.
  33. Abbasi H, Dastgheib SA, Hadadan A, Karimi-Zarchi M, Javaheri A, Meibodi B, et al. Association of endothelial nitric oxide synthase 894G > T polymorphism with preeclampsia risk: A systematic review and meta-analysis based on 35 studies. Fetal Pediatr Pathol 2021; 40(5): 455-70.
  34. Namazi A, Abedinzadeh M, Nourbaksh P, Neamatzadeh H. Association between the XRCC3 Thr241Met polymorphism and risk of colorectal cancer: A meta-analysis of 5,193 cases and 6,645 controls. Asian Pac J Cancer Prev 2015; 16(6): 2263-8.
World Journal of Peri and Neonatology
Volume 5, Issue 2
December 2022
Pages 83-95

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History

  • Receive Date: 26 December 2022
  • Accept Date: 26 December 2022

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