Amniocentesis Complications in Yazd Baghaeipour Polyclinic: A Cross-Sectional Study

Document Type : Original Article

Authors

1 Ali ben Abitaleb Medical School, Islamic Azad University, Yazd, Iran

2 Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Department of Obstetrics and Gynecology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Abstract

Background: Amniocentesis, like other invasive methods, has complications such as abortion, premature rupture - second pregnancy and at 29 weeks of membranes, infection, bleeding, etc. Here, we aimed to study the complications of amniocentesis in pregnant women.
Methods: This descriptive cross-sectional study was included 409 women with positive first and second stage screening or required amniocentesis referred to Baghaeipour Clinic in 2017. Data was collected by a pre-prepared questionnaire.
Results: The mean age of the patients and gestational age was
33.49 ± 6.51 years and 17.39 ± 1.36  weeks, respectively. 132 patients (32.2%) had a history of abortion. Regarding the frequency of needle passage through the placenta, the results showed that in 369 people (90.2%) the needle did not pass through the placenta and in 40 people (9.8%). The needle has passed through the pair. Regarding the frequency distribution of amniocentesis complications, fetal death in (2.4%), bleeding in (2.2%) and PROM (1.7%) were observed in patients and no case of infection and abortion was observed. In terms of age, gestational age, gestational number, placental location, needle passage, aspirated fluid color, history of abortion and type of delivery, there were no significant differences.
Conclusion: In this study the most common complication of amniocentesis was fetal death (2.4%), followed by bleeding and Spotting (2.2%), PROM (1.7%), infection and abortion, respectively.

Keywords


  1. Gibbs, RS, Karlan BY, Haney, AF, Nygaard, IE. Danforth obstetrics and gynecology. 10th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008.
  2. Rutherford SE, Phelan JP, Smith CV, Jacobs N. The four-quadrant assessment of amniotic fluid volume: an adjunct to antepartum fetal heart rate testing. Obstet Gynecol 1987; 70(3 pt 1): 353-6.
  3. Moore TR, Cayle JE. The amniotic fluid index in normal human pregnancy. Am J Obstet Gynecol 1990; 162(5): 1168-73.
  4. Modena AB, Fieni S. Amniotic fluid dynamic. Acta Biomed 2004; 75(Supp1): 11-3.
  5. Nassar AH, Martin D, González-Quintero VH, Gómez-Marín O, Salman F, Gutierrez A, et al. Genetic amniocentesis complications: is the incidence overrated? Gynecol Obstet invest 2004; 58(2): 100-4.
  6. Anuwutnavin S, Chanprapaph P, Ruangvutilert P, Eammatta M, Tontisirin P. Short‐term outcomes after second‐trimester genetic amniocentesis in Siriraj Hospital. Int J Gynecol Obstet 2014; 124(3): 222-5.
  7. Özcan HÇ, Uğur MG, Sucu S, Mustafa A, Tepe NB, Balat Ö. Summary of 2185 prenatal invasive procedures in a single center: A retrospective analysis. Turk J Obstet Gynecol 2017; 14(2): 114-20.
  8. Hassanzadeh R, Naghizadeh S, Azari S, Ebrahimpour Mirzarezaei M. Diagnosis of Aneuploidies by amniocentesis in high risk cases of first trimester screening test. Iran J Obstet Gynecol Infertil 2014, 17(119): 18-26. [In Persian].
  9. Monzavi Sani R, Savadkuhi F, Rohani Z. Chorionic villus sampling complications in prenatal diagnosis of thalassemia major. Iran J Radiol 2010; 7(2): 101-4. [In Persian].
  10. Niromanesh S, Mousavi N, Rahimi F, Shirazi M. Pregnancy outcome in amniocentesis and chorionic villous sampling: ten- year report. Tehran Univ Med J 2016; 74(6): 400-7.
    [In Persian].
  11. Pitukkijronnakorn S, Promsonthi P, Panburana P, Udomsubpayakul U, Chittacharoen A. Fetal loss associated with second trimester amniocentesis. Arch Gynecol Obstet 2011; 284(4): 793-7.
  12. Theodora M, Antsaklis A, Antsaklis P, Blanas K, Daskalakis G, Sindos M, et al. Fetal loss following second trimester amniocentesis. Who is at greater risk? How to counsel pregnant women? J Matern Fetal Neonatal Medi 2016; 29(4): 590-5.
  13. Shahbazian N, Barati M, Arian P, Saadati N. Comparison of complications of chorionic villus sampling and amniocentesis. Int J Fertil Steril 2012; 5(4): 241-4.
  14. Cederholm M, Haglund B, Axelsson O. Maternal complications following amniocentesis and chorionic villus sampling for prenatal karyotyping. BJOG 2003; 110(4): 392-9.
  15. Shirazi M, Mohseni M, Ghajarzadeh M. Complications, indications and results of two screening methods: amniocentesis and chorionic villus sampling. Academic Journal of Surgery 2015; 2(1-2): 23-6.
  16. Tara F, Lotfalizadeh M. Evaluation of early and late complications of amniocentesis in Ommolbanin Hospital in Mashhad, Iran 2014-16. Iran J Obstet Gynecol Infertil 2018; 21(3): 1-4. [In Persian].