Journal of Integrated Maternal and Pediatric Care

Editorial

A Message from the Editorial Board: Keeping Our Journal Strong for Maternal and Neonatal Health

Mahta Mazaheri

Volume 8, Issue 1 , May 2026, Pages 1-2

https://doi.org/10.18502/wjpn.v8i1.21578

Abstract

In 2025, the journal faced an unexpected pause in publication and delays in uploading several articles because of internal restructuring and external disruptions. The editorial transition ... Read More

Scientific Review

Prevalence of Spontaneous and Induced Abortion and Its Associated Factors in Iran: A Narrative Review

Zohreh Sahebi; Azam Zare Arashlouei; Mahshid Bokaie

Volume 8, Issue 1 , May 2026, Pages 3-12

https://doi.org/10.18502/wjpn.v8i1.21579

Abstract

Background: The primary goal of this study was to determine the prevalence of various abortion types and to identify the most significant associated factors within Iran by aggregating ... Read More

Scientific Review

Dynamic Extracellular Matrix Remodeling and Immune Reprogramming in the Postpartum Mammary Gland: Implications for Maternal Health and Breast Cancer Risk

Samane Heydari; Sadegh Safaei

Volume 8, Issue 1 , May 2026, Pages 13-25

https://doi.org/10.18502/wjpn.v8i1.21580

Abstract

The mammary gland is a uniquely dynamic organ, undergoing profound structural and functional transformations throughout the pregnancy-lactation-involution cycle. These changes are orchestrated ... Read More

Scientific Review

AI Applications in Diagnosing Rare Genetic Disorders

Melina Bitarafan

Volume 8, Issue 1 , May 2026, Pages 26-30

https://doi.org/10.18502/wjpn.v8i1.21581

Abstract

Rare diseases (RDs) represent a broad category of conditions that individually affect a relatively small proportion of the population but collectively impact millions of people worldwide. ... Read More

Original Article

Effect of Body Positioning on Gastrointestinal Tolerance in Very-Low-Birth-Weight Preterm Infants Fed Enriched Breast Milk in a NICU in Yazd, Iran

Marzieh Pourakrami; Mohamad Hosein Lookzadeh; Zahra Pourmovahed

Volume 8, Issue 1 , May 2026, Pages 31-41

https://doi.org/10.18502/wjpn.v8i1.21582

Abstract

Background: Feeding preterm infants with unfortified breast milk can lead to growth delays and nutritional deficiencies. To address this while promoting breastfeeding, commercial human ... Read More

Original Article

Investigating the Factors Influencing the Preference for Cesarean Sections among First-Time Pregnant Women Visiting Comprehensive Health Service Centers in Yazd City

Hasan Jafari; Mohammad Kazem Rahimi; Najmeh Asadi; Farnoosh Ghomi

Volume 8, Issue 1 , May 2026, Pages 42-49

https://doi.org/10.18502/wjpn.v8i1.21583

Abstract

Background: For numerous women, the selection of a childbirth method presents a significant decision, often shaped by a multitude of factors, notably those of a social and familial ... Read More

Original Article

Chest CT Abnormalities and Disease Severity in Hospitalized Children with COVID 19: A Retrospective Cohort Study

Bozorgmehr Samanian; Mehran Karimi; Amir Pasha Amel Shahbaz; Farimah Shamsi; Reza Nafisi Moghadam

Volume 8, Issue 1 , May 2026, Pages 50-58

https://doi.org/10.18502/wjpn.v8i1.21584

Abstract

Background: Although COVID-19 is generally milder in children, a subset develops severe pulmonary involvement requiring hospitalization. Evidence linking chest CT abnormalities to clinical ... Read More

Original Article

A Comparison between the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants

Zoheir Fardid; Seyed Reza Mirjalili; Mahmood Noorishadkam; Mahmood Vakili; Maryam Saeida-Ardekani; Mohamad Hosein Lookzadeh

Volume 8, Issue 1 , May 2026, Pages 59-66

https://doi.org/10.18502/wjpn.v8i1.21585

Abstract

Background: Respiratory distress syndrome (RDS) in premature infants results from surfactant deficiency. Given the high cost and limited availability of Curosurf, we compared its outcomes ... Read More

Scientific Review

Integration of Artificial Intelligence, Multi-Omics, and Digital Health for Precision Prevention of Preterm Birth: A Structured Narrative Review

Mahshid Bokaie; Roghayeh Ijabi

Articles in Press, Accepted Manuscript, Available Online from 20 July 2026

Abstract

Background: Preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality worldwide. Conventional prediction methods have limited accuracy, highlighting the need for ... Read More Background: Preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality worldwide. Conventional prediction methods have limited accuracy, highlighting the need for precision prevention strategies that integrate molecular, clinical, and digital health data. Methods: A structured narrative review was conducted using PubMed, Scopus, and Web of Science to identify relevant studies published between 2010 and 2024. A total of 21 relevant studies were included and narratively synthesized into three thematic areas: multi-omics technologies, artificial intelligence (AI)-based prediction models, and digital health approaches for PTB prevention. Results: Multi-omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and microbiome profiling, improved understanding of PTB pathophysiology and identified biomarkers associated with inflammation, immune dysregulation, oxidative stress, extracellular matrix remodeling, and placental dysfunction. AI models integrating clinical, imaging, laboratory, and molecular data demonstrated promising predictive performance, with reported area under the receiver operating characteristic curve (AUC) values ranging from approximately 0.61 to 0.94 where available. Ensemble machine learning and deep learning algorithms generally outperformed conventional statistical approaches. Digital health technologies, including wearable devices and remote monitoring systems, supported continuous maternal assessment and facilitated earlier identification of women at increased risk. However, limited external validation, heterogeneous datasets, model interpretability, and data privacy remain important challenges to clinical implementation. Conclusion: The integration of multi-omics technologies, AI, and digital health represents a promising strategy for precision prevention of PTB. Future research should prioritize multicenter validation, standardized data integration, and the development of transparent and clinically applicable AI models to facilitate translation into routine obstetric care.

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Scientific Review

Breast Milk Stem Cells and Maternal Microchimerism: Mechanisms and Clinical Implications

Sadegh Safaei

Articles in Press, Accepted Manuscript, Available Online from 01 July 2026

Abstract

Human breast milk is recognized as a living, cell-rich fluid that provides viable mother cells along with supplementary nutrients and soluble immunomodulators. It contains heterogeneous ... Read More

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Scientific Review

The Role of Prevention Programs in Reducing Unsafe Abortions: A Narrative Review

Zahra Rezaeikoopaei; Tahmineh Farajkhoda

Articles in Press, Accepted Manuscript, Available Online from 20 July 2026

Abstract

Unsafe abortion remains one of the major challenges facing health systems worldwide, and unintended pregnancy is a common precursor to unsafe abortion. One of the most important serious ... Read More

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Original Article

Chest Radiographic Findings in Hospitalized Children with COVID-19: A Cross-Sectional Study in Yazd, Iran

Ahmad Shajari; Saeideh Daya; Mehran Karimi; Amir Pasha Amel Shahbaz; Farimah Shamsi; Reza Nafisi Moghadam; Elahe Akbarian

Articles in Press, Accepted Manuscript, Available Online from 21 July 2026

Abstract

Background: Chest X‑ray (CXR) patterns in pediatric COVID‑19 are not well described. We aimed to characterize CXR findings in hospitalized children and to examine their associations ... Read More

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Original Article

Clinical Manifestations, Treatment and Outcomes of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Single-Center Experience from Iran

Mohammad Emad Sharifi; Farzad Ferdosian; Mehran Karimi; Naeimeh Naserzadeh; Zahra Nafei; Niloufar Vaziri Bozorg; Shekoofeh Savabieh

Articles in Press, Accepted Manuscript, Available Online from 22 July 2026

Abstract

Background Multisystem inflammatory syndrome in children (MIS-C) is a documented complication arising from SARS-CoV-2 infection. Even pediatric patients who present with mild initial ... Read More Background Multisystem inflammatory syndrome in children (MIS-C) is a documented complication arising from SARS-CoV-2 infection. Even pediatric patients who present with mild initial COVID-19 symptoms may subsequently experience severe morbidity or mortality due to MIS-C; therefore, early identification and prompt clinical management are essential for achieving favorable outcomes. This study aims to assess the clinical characteristics, therapeutic strategies, and patient outcomes among children diagnosed with MIS-C in Yazd, Iran. Methods This study enrolled all pediatric patients to Shahid Sadoughi Hospital in Yazd, Iran, who presented with either suspected or confirmed MIS-C between March 2020 and March 2021. Comprehensive medical records were examined to extract data regarding demographics, clinical symptoms, laboratory findings, imaging results, and treatment modalities. Clinical patterns were identified through data using SPSS software, and descriptive statistics along with Fisher’s exact test were employed to evaluate outcomes relative to disease severity. Results The study included forty children (52.5% males, 47.5% females) with the mean age of 7.3 years. Clinical presentation was dominated by fever(87.5%), followed by gastrointestinal distress (57.5%), and mucocutaneous abnormalities (20%). The most frequently affected organs were the digestive, respiratory, and neurological systems. 75% needed 1-7 days of hospitalization, while 22.5% needed 8-14 days. 25.5% had severe disease, 47.5% moderate, and 27.5% mild. Remdesivir (40%), corticosteroids (52.5%), and intravenous immunoglobulin (47.5%) were used as treatment. Notably, the mortality rate observed in this cohort was a 22.5% (9 out of 40), which exceeds the rates reported in several international studies. Conclusions Compared with international reports, this study shows a higher mortality rate (22.5%), emphasizing the need for early detection, prompt treatment, and increased awareness. Results emphasize the importance of timely referrals and aggressive immunomodulation. Incidence and complications of MIS-C may be reduced through vaccination. To better understand regional variations in MIS-C outcomes, further large-scale studies are warranted.

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Original Article

Clinicopathological Characteristics and Outcomes of Pediatric Retroperitoneal Lesions: A Retrospective Study

Saadat Eslami; Maryam Vajihinejad; Mahmood Reza Roknaldini

Articles in Press, Accepted Manuscript, Available Online from 22 July 2026

Abstract

Background: Pediatric retroperitoneal lesions are rare and heterogeneous, often presenting with nonspecific symptoms that complicate early diagnosis. Understanding their clinical and ... Read More Background: Pediatric retroperitoneal lesions are rare and heterogeneous, often presenting with nonspecific symptoms that complicate early diagnosis. Understanding their clinical and pathological characteristics is essential for improving management and outcomes. This study evaluated the clinical, pathological, and survival features of pediatric retroperitoneal lesions.Methods: In this retrospective cross-sectional study, 14 patients younger than 18 years with histologically confirmed retroperitoneal lesions, treated at Shahid Sadoughi Hospital, Yazd, Iran, between 2016 and 2021, were evaluated. Data on demographics, clinical presentation, tumor origin, pathological diagnosis, metastasis, recurrence, and survival were collected. Statistical analyses included descriptive statistics, Chi-square tests, and Kaplan–Meier survival analysis.Results: The mean age was 13.9 ± 3.38 years, with equal sex distribution. Secondary tumors were the most common lesions (64.3%), followed by primary malignant (21.4%) and primary benign tumors (14.3%). The retroperitoneum was the most frequent site of origin (50%). Common presentations included nausea and vomiting (64.3%), abdominal pain (50%), and urinary symptoms (50%). Metastasis was observed in 71.4% of patients, and recurrence in 21.4%. Five-year survival rates were 100% for primary benign tumors, 73.9% for primary malignant tumors, and 67.5% for secondary tumors. Recurrence was significantly associated with poorer survival (p = 0.027).Conclusions: In this small cohort, pediatric retroperitoneal lesions were predominantly secondary tumors, while lymphoma was the most common primary malignancy. Their nonspecific presentation highlights the importance of imaging and pathological evaluation. Tumor recurrence was associated with reduced survival, suggesting prognostic significance and emphasizing the need for long-term follow-up. These findings are preliminary and require validation in larger studies.

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Original Article

Prevalence of Gastrointestinal Symptoms in Children with COVID-19 Hospitalized at Shahid Sadoughi Hospital in Yazd

Majid Aflatoonian; Mehran Karimi; Farzad Ferdosian; Roohollah Edalatkhah; Shiva Rezaei

Articles in Press, Accepted Manuscript, Available Online from 22 July 2026

Abstract

Background: COVID-19 affects respiratory system, but GI manifestations are recognized, particularly in children. These symptoms may precede or accompany respiratory manifestations, ... Read More

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Volume 8 (2025)

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

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