Mortality Rate in Hospitalized Pediatric with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis

Document Type : Systematic Review


1 Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran

2 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

5 Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran


Background: There is little data on the mortality rate and severity of COVID-19 infection in pediatric. This knowledge is particularly significant because pneumonia is the original leading cause of death in pediatric worldwide. This systematic review and meta-analysis aims to evaluate the mortality rate of COVID-19 in the pediatric population in Iran.
Methods: A systematic review and meta-analysis of the publications was conducted by PRISMA guidelines to be aware of Covid-19 child mortality. PubMed, Google Scholar, Embase, Medline databases, and Persian database were searched for publications on pediatric COVID-19 infections published in Iran with a focus on Mortality of Pediatric with Covid-19 infection in Iran between January 1st to April 30 th, 2021. Articles representing at least one Pediatric with and without comorbidities, COVID-19 infection, and informed outcomes were contained.
Results: Eight studies including three case series, and five retrospective Cross-sectional, altogether representing a total of 238 pediatric patients with COVID-19 were included in this Meta-Analysis. Of this population, 13 patients died. In this study, the average age of cases was 6.7%. The mortality rate of pediatric that was hospitalized with COVID-19 was 9% (95% CI 0.055-0.146). Also, pediatric with comorbidities had a higher risk of COVID-19 related mortality.
Conclusion: Unlike adults, most infected children are asymptomatic and are not usually hospitalized. Pediatric with underlying conditions has a more increased risk of severe COVID-19 and related to mortality than Pediatric without underlying illness. Extra attention may be required for pediatric with comorbidities and younger Pediatric. Our sample size was very small and more studies with large sample sizes are needed to assess the exact mortality rate in the pediatric population in Iran.


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Articles in Press, Accepted Manuscript
Available Online from 27 June 2022
  • Receive Date: 27 June 2022
  • Accept Date: 27 June 2022
  • First Publish Date: 27 June 2022