Outcome of a Neonate Born to a Mother with COVID-19: A Case Report of Vertical Transmission

Document Type : Case Report


1 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Background: Although COVID-19 in pregnant women and their neonates has been verified, its impact on neonates born to infected mothers has remained unclear and there is not enough evidence about how this vertical transmission occurs.
Case Report: In this case report, we explained that a neonate girl was born to a mother with COVID-19 infection. Our main goal was to focus on the follow-up and outcome of the neonate. The neonate was at GA = 28 weeks who was born by cesarean section due to respiratory distress of her mother. Also on day 18, she experienced recurrent unilateral seizures so the sample of her cerebrospinal fluid (CSF) was examined.
Results: The neonate had a positive reverse transcription polymerase chain reaction (RT-PCR) test for COVID-19, while this neonate after birth, due to mother’s positive PCR, immediately was isolated from the operating room. The neonate’s nasal sample was positive for more than 18 days. Twenty-six days after birth, the neonate was re-evaluated for clinical laboratories, all of which were normal and she had favorable outcomes.
Conclusion: In our case report despite the neonate was premature and had seizures, she had favorable outcomes because we quickly started treatment and supportive measures. It is recommended; Symptomatic neonates born to infected mothers must be evaluated for COVID-19 to start proper treatment and quarantine. Additional studies are needed to evaluate the outcomes of COVID-19 in neonates and how to minimize the risk of this disease in neonates.


  1. Baghalsafa F, Neamatzadeh H, Ekraminasab S. Death of a 3 month-old infected infant with dilated cardiomyopathy after COVID-19 infection: A case report. World J Peri & Neonatol 2021; 4(1): 60-4.
  2. Cui Y, Tian M, Huang D, Wang X, Huang Y, Fan L, et al. A 55-day-old female infant infected with 2019 novel coronavirus disease: Presenting with pneumonia, liver injury, and heart damage. J Infect Dis 2020; 221(11): 1775-80.
  3. Jordan RE, Adab P, Cheng KK. COVID-19: Risk factors for severe disease and death. BMJ 2020; 368: m1198.
  4. Chi H, Chiu N, Tai YL, Chang HY, Lin CH, Sung YH, et al. Clinical features of neonates born to mothers with coronavirus disease-2019 : A systematic review of 105 neonates. J Microbiol Immunol Infect 2021; 54(1): 69-76.
  5. Li LQ, Huang T, Wang YO, Wang ZP, Liang Y, Huang TB, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol 2020; 92(6): 577-83.
  6. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020; 382(13): 1199-207.
  7. Hinojosa-Velasco A, de Oca PVB, García-Sosa LE, Mendoza-Durán JG, Pérez-Méndez MJ, Dávila-González E, et al. A case report of newborn infant with severe COVID-19 in Mexico : Detection of SARS-CoV-2 in human breast milk and stool. Int J Infect Dis 2020; 100: 21-4.
  8. Huseynova RA, Mahmoud LAB, Huseynov O, Almalkey M, Almotiri AA, et al. CASE REPORT A neonate born to an infected COVID-19 mother was tested positive just 24 hours after its birth. Clin Case Rep 2021; 9(4): 1954-7.
  9. Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-NCOV (SARS-CoV-2) infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections. Viruses 2020; 12(2): 194.
  10. Karimi-Zarchi M, Schwartz DA, Dastgheib SA, Bahrami R, Javaheri A, et al. A meta-analysis for prevalence of cesarean section, preterm birth, stillbirth, and low birth weight deliveries in infected pregnant women with COVID-19. World J Peri & Neonatol 2021; 4(1): 23-39.
  11. Gatta AND, Rizzo R, Pilu G, Simonazzi G. Coronavirus disease 2019 during pregnancy: A systematic review of reported cases. Am J Obstet Gynecol 2020; 223(1): 36-41.
  12. Akbarian-rad Z, Mojaveri MH, Bouzari Z, Sadeghi F, Yahyapour Y, Naeimi Rad M, et al. Neonatal outcomes in pregnant women infected with COVID-19 in Babol, North of Iran : A retrospective study with short-term follow-up. Infect Dis Obstet Gynecol 2021: 9952701.
  13. Hosseini MS, Hosseini A, Ghaffari E, Radfar M, Shirvani F, Tabatabai S, et al. Evaluation of clinical outcomes of neonates born to mothers with coronavirus (COVID-19) in Shahid Beheshti Hospitals. J Edu Health Promot 2021; 10(1): 173.
  14. Sagheb S, Lamsehchi A, Jafary M, Atef-Yekta R, Sadeghi K. Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report. Ital J Pediatr 2020; 46(1): 137.
  15. Bahrami R, Ekraminasab S, Asadian F. A survey on cardiac complications of COVID-19 in infants. World J Peri & Neonatol 2021; 4(1): 50-9.
  16. Dumitriu D, Emeruwa UN, Hanft E, Liao GV, Ludwig E, Walzer L, et al. Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City. JAMA Pediatr 2021; 175(2): 157-67.
  17. Rafiei Tabatabaei S, Fallahi M, Boskabadi A, Taslimi Taleghani N, Pajouhandeh F, Tabatabaee S, et al. COVID-19 in neonates, a case series study from Tertiary Neonatal Centers in Iran. Arch Pediatr Infect Dis 2021; 9(4): 7.
Volume 4, Issue 2
December 2021
Pages 124-129
  • Receive Date: 16 February 2022
  • Accept Date: 16 February 2022
  • First Publish Date: 16 February 2022