A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19

Document Type : Systematic Review


1 Department of Obstetrics and Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Pathology, Medical College of Georgia, Augusta, GA, USA

3 Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Endometriosis Research Center, Iran University of Medical Sciences, Firoozgar Hospital, Tehran, Iran

5 Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran

6 Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran

7 Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

8 Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

9 Department of Obstetrics and Gynecology, Yazd Branch, Islamic Azad University, Yazd, Iran

10 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

11 Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


Background: Most pregnant women with COVID-19 develop less severe form of the disease, with few cases of severe maternal morbidity and mortality, or perinatal deaths. This meta-analysis was conducted to evaluate the frequency of miscarriage in pregnant women affected by the SARS-COV-2 infection.
Methods: A comprehensive search was performed in online databases to identify all relevant studies published up to 5th March 2021. Case-control studies and case series reported the frequency of miscarriage in pregnant women with COVID-19 was selected.
Results: A total of 22 studies with 8591 infected pregnant women and 141 abortions were selected. The frequency of miscarriage was 3.9% (95% CI 0.023-0.063) in infected pregnant women with COVID-19. It had the highest frequency in Asian (6.3%) followed by European (2.9%), West-Asian (2.5%) and Caucasian (2.3%) infected pregnant women. Moreover, stratified analysis by country showed that the frequency of miscarriage is the highest in Chinese (11.3%) followed by Italy (11.2%), India (2.7%), Turkey (2.2%), USA (1.2%) and France (0.9%) infected pregnant women.
Conclusion: Our pooled data revealed that the frequencies of miscarriage in pregnant women with SARS-COV-2 infection were 3.9%.


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Volume 4, Issue 2
December 2021
Pages 104-114
  • Receive Date: 10 February 2022
  • Accept Date: 10 February 2022
  • First Publish Date: 10 February 2022